Lord’s paradox

S. Senn: To infinity and beyond: how big are your data, really? (guest post)

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Stephen Senn
Consultant Statistician
Edinburgh

What is this you boast about?

Failure to understand components of variation is the source of much mischief. It can lead researchers to overlook that they can be rich in data-points but poor in information. The important thing is always to understand what varies in the data you have, and to what extent your design, and the purpose you have in mind, master it. The result of failing to understand this can be that you mistakenly calculate standard errors of your estimates that are too small because you divide the variance by an n that is too big. In fact, the problems can go further than this, since you may even pick up the wrong covariance and hence use inappropriate regression coefficients to adjust your estimates.

I shall illustrate this point using clinical trials in asthma. Continue reading

Categories: Lord's paradox, S. Senn | 5 Comments

Stephen Senn: On the level. Why block structure matters and its relevance to Lord’s paradox (Guest Post)

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Stephen Senn
Consultant Statistician
Edinburgh

Introduction

In a previous post I considered Lord’s paradox from the perspective of the ‘Rothamsted School’ and its approach to the analysis of experiments. I now illustrate this in some detail giving an example.

What I shall do

I have simulated data from an experiment in which two diets have been compared in 20 student halls of residence, each diet having been applied to 10 halls. I shall assume that the halls have been randomly allocated the diet and that in each hall 10 students have been randomly chosen to have their weights recorded at the beginning of the academic year and again at the end. Continue reading

Categories: Lord's paradox, Statistical Inference as Severe Testing, Stephen Senn | 34 Comments

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