Stephen Senn
Consultant Statistician
Edinburgh
Correcting errors about corrected estimates
Randomised clinical trials are a powerful tool for investigating the effects of treatments. Given appropriate design, conduct and analysis they can deliver good estimates of effects. The key feature is concurrent control. Without concurrent control, randomisation is impossible. Randomisation is necessary, although not sufficient, for effective blinding. It also is an appropriate way to deal with unmeasured predictors, that is to say suspected but unobserved factors that might also affect outcome. It does this by ensuring that, in the absence of any treatment effect, the expected value of variation between and within groups is the same. Furthermore, probabilities regarding the relative variation can be delivered and this is what is necessary for valid inference. Continue reading

























