Author Archives: Mayo

Deconstructing Larry Wasserman

 Greek dancing lady gold SavoyLarry Wasserman (“Normal Deviate”) has announced he will stop blogging (for now at least). That means we’re losing one of the wisest blog-voices on issues relevant to statistical foundations (among many other areas in statistics). Whether this lures him back or reaffirms his decision to stay away, I thought I’d reblog my (2012) “deconstruction” of him (in relation to a paper linked below)[i]

Deconstructing Larry Wasserman [i] by D. Mayo

The temptation is strong, but I shall refrain from using the whole post to deconstruct Al Franken’s 2003 quip about media bias (from Lies and Lying Liars Who Tell Them: A Fair and Balanced Look at the Right), with which Larry Wasserman begins his paper “Low Assumptions, High Dimensions” (2011) in his contribution to Rationality, Markets and Morals (RMM) Special Topic: Statistical Science and Philosophy of Science:

Wasserman: There is a joke about media bias from the comedian Al Franken:
‘To make the argument that the media has a left- or right-wing, or a liberal or a conservative bias, is like asking if the problem with Al-Qaeda is: do they use too much oil in their hummus?’

According to Wasserman, “a similar comment could be applied to the usual debates in the foundations of statistical inference.”

Although it’s not altogether clear what Wasserman means by his analogy with comedian (now senator) Franken, it’s clear enough what Franken meant if we follow up the quip with the next sentence in his text (which Wasserman omits): “The problem with al Qaeda is that they’re trying to kill us!” (p. 1). The rest of Franken’s opening chapter is not about al Qaeda but about bias in media. Conservatives, he says, decry what they claim is a liberal bias in mainstream media. Franken rejects their claim.

The mainstream media does not have a liberal bias. And for all their other biases . . . , the mainstream media . . . at least try to be fair. …There is, however, a right-wing media. . . . They are biased. And they have an agenda…The members of the right-wing media are not interested in conveying the truth… . They are an indispensable component of the right-wing machine that has taken over our country… .   We have to be vigilant.  And we have to be more than vigilant.  We have to fight back… . Let’s call them what they are: liars. Lying, lying, liars. (Franken, pp. 3-4)

When I read this in 2004 (when Bush was in office), I couldn’t have agreed more. How things change*. Now, of course, any argument that swerves from the politically correct is by definition unsound, irrelevant, and/ or biased. [ii](December 2016 update: This just shows how things get topsy-turvy every 5-8 years. Now we have extremes on both sides.)

But what does this have to do with Bayesian-frequentist foundations? What is Wasserman, deep down, really trying to tell us by way of this analogy (if only subliminally)? Such are my ponderings—and thus this deconstruction.  (I will invite your “U-Phils” at the end[a].) I will allude to passages from my contribution to  RMM (2011) (in red).

A.What Is the Foundational Issue?

Wasserman: To me, the most pressing foundational question is: how do we reconcile the two most powerful needs in modern statistics: the need to make methods assumption free and the need to make methods work in high dimensions… . The Bayes-Frequentist debate is not irrelevant but it is not as central as it once was. (p. 201)

One may wonder why he calls this a foundational issue, as opposed to, say, a technical one. I will assume he means what he says and attempt to extract his meaning by looking through a foundational lens. Continue reading

Categories: Philosophy of Statistics, Statistics, U-Phil | Tags: , , , | 10 Comments

Mascots of Bayesneon statistics (rejected post)

bayes_theorem (see rejected posts)

Categories: Bayesian/frequentist, Rejected Posts | Leave a comment

“Bad Arguments” (a book by Ali Almossawi)

I received a new book today as a present[i]: “(An illustrated book of) Bad Arguments” (Ali Almossawi 2013) [ii]. I wish I’d had it for the critical thinking class I just completed! Here’s the illustration it gives for “hasty generalization”.

hasty 001

The author allows it to be accessed here, I just discovered.

But it’s not just a clever book of cartoons: it does a better job than most texts in its conception of bad inductive arguments. Recall my post, “A critical Look at Critical Thinking”–prior to the start of my class–in which I explained why critical thinking is actually a sophisticated affair that philosophers have never fully sorted out. (We may teach it before “baby (symbolic) logic”, but it’s really very grown-up.) I gave my recommendation there as to where probability ought to enter in understanding bad (inductive) arguments, and Almossawi’s conception is in sync with mine[iii]. The inductive qualification is on the mode of inferring, rather than on the conclusion (or inferential claim H) itself*. The difference might seem subtle, but I swear it’s at the heart of many contemporary controversies about statistical inference, and the most serious among them.

[i] From Aris Spanos—thanks Aris.

[ii] Ali Almossawi, whom I never heard of before, has masters degrees in engineering/CS from MIT and CMU, and is a data visualization designer. The illustrator is: Alejandro Giraldo
[iii] I haven’t read all of it, but I doubt I’ll find any howlers.

*About the mode of inferring: What’s its capability to have avoided (alerted us to) the ways it would be wrong to infer H (from the data).

 

Categories: critical thinking, Statistics | 1 Comment

U-Phil: Deconstructions [of J. Berger]: Irony & Bad Faith 3

Memory Lane: 2 years ago:
My efficient Errorstat Blogpeople1 have put forward the following 3 reader-contributed interpretive efforts2 as a result of the “deconstruction” exercise from December 11, (mine, from the earlier blog, is at the end) of what I consider:

“….an especially intriguing remark by Jim Berger that I think bears upon the current mindset (Jim is aware of my efforts):

Too often I see people pretending to be subjectivists, and then using “weakly informative” priors that the objective Bayesian community knows are terrible and will give ridiculous answers; subjectivism is then being used as a shield to hide ignorance. . . . In my own more provocative moments, I claim that the only true subjectivists are the objective Bayesians, because they refuse to use subjectivism as a shield against criticism of sloppy pseudo-Bayesian practice. (Berger 2006, 463)” (From blogpost, Dec. 11, 2011)
_________________________________________________
Andrew Gelman:

The statistics literature is big enough that I assume there really is some bad stuff out there that Berger is reacting to, but I think that when he’s talking about weakly informative priors, Berger is not referring to the work in this area that I like, as I think of weakly informative priors as specifically being designed to give answers that are _not_ “ridiculous.”

Keeping things unridiculous is what regularization’s all about, and one challenge of regularization (as compared to pure subjective priors) is that the answer to the question, What is a good regularizing prior?, will depend on the likelihood.  There’s a lot of interesting theory and practice relating to weakly informative priors for regularization, a lot out there that goes beyond the idea of noninformativity.

To put it another way:  We all know that there’s no such thing as a purely noninformative prior:  any model conveys some information.  But, more and more, I’m coming across applied problems where I wouldn’t want to be noninformative even if I could, problems where some weak prior information regularizes my inferences and keeps them sane and under control. Continue reading

Categories: Gelman, Irony and Bad Faith, J. Berger, Statistics, U-Phil | Tags: , , , | 3 Comments

A. Spanos lecture on “Frequentist Hypothesis Testing”

may-4-8-aris-spanos-e2809contology-methodology-in-statistical-modelinge2809d

Aris Spanos

I attended a lecture by Aris Spanos to his graduate econometrics class here at Va Tech last week[i]. This course, which Spanos teaches every fall, gives a superb illumination of the disparate pieces involved in statistical inference and modeling, and affords clear foundations for how they are linked together. His slides follow the intro section. Some examples with severity assessments are also included.

Frequentist Hypothesis Testing: A Coherent Approach

Aris Spanos

1    Inherent difficulties in learning statistical testing

Statistical testing is arguably  the  most  important, but  also the  most difficult  and  confusing chapter of statistical inference  for several  reasons, including  the following.

(i) The need to introduce numerous new notions, concepts and procedures before one can paint —  even in broad brushes —  a coherent picture  of hypothesis  testing.

(ii) The current textbook discussion of statistical testing is both highly confusing and confused.  There  are several sources of confusion.

  • (a) Testing is conceptually one of the most sophisticated sub-fields of any scientific discipline.
  • (b) Inadequate knowledge by textbook writers who often do not have  the  technical  skills to read  and  understand the  original  sources, and  have to rely on second hand  accounts  of previous  textbook writers that are  often  misleading  or just  outright erroneous.   In most  of these  textbooks hypothesis  testing  is poorly  explained  as  an  idiot’s guide to combining off-the-shelf formulae with statistical tables like the Normal, the Student’s t, the chi-square,  etc., where the underlying  statistical  model that gives rise to the testing procedure  is hidden  in the background.
  • (c)  The  misleading  portrayal of Neyman-Pearson testing  as essentially  decision-theoretic in nature, when in fact the latter has much greater  affinity with the Bayesian rather than the frequentist inference.
  • (d)  A deliberate attempt to distort and  cannibalize  frequentist testing by certain  Bayesian drumbeaters who revel in (unfairly)  maligning frequentist inference in their  attempts to motivate their  preferred view on statistical inference.

(iii) The  discussion of frequentist testing  is rather incomplete  in so far as it has been beleaguered by serious foundational problems since the 1930s. As a result, different applied fields have generated their own secondary  literatures attempting to address  these  problems,  but  often making  things  much  worse!  Indeed,  in some fields like psychology  it has reached the stage where one has to correct the ‘corrections’ of those chastising  the initial  correctors!

In an attempt to alleviate  problem  (i),  the discussion  that follows uses a sketchy historical  development of frequentist testing.  To ameliorate problem (ii), the discussion includes ‘red flag’ pointers (¥) designed to highlight important points that shed light on certain  erroneous  in- terpretations or misleading arguments.  The discussion will pay special attention to (iii), addressing  some of the key foundational problems.

[i] It is based on Ch. 14 of Spanos (1999) Probability Theory and Statistical Inference. Cambridge[ii].

[ii] You can win a free copy of this 700+ page text by creating a simple palindrome! https://errorstatistics.com/palindrome/march-contest/

Categories: Bayesian/frequentist, Error Statistics, Severity, significance tests, Statistics | Tags: | 36 Comments

Surprising Facts about Surprising Facts

Mayo mirror

double-counting

A paper of mine on “double-counting” and novel evidence just came out: “Some surprising facts about (the problem of) surprising facts” in Studies in History and Philosophy of Science (2013), http://dx.doi.org/10.1016/j.shpsa.2013.10.005

ABSTRACT: A common intuition about evidence is that if data x have been used to construct a hypothesis H, then x should not be used again in support of H. It is no surprise that x fits H, if H was deliberately constructed to accord with x. The question of when and why we should avoid such ‘‘double-counting’’ continues to be debated in philosophy and statistics. It arises as a prohibition against data mining, hunting for significance, tuning on the signal, and ad hoc hypotheses, and as a preference for predesignated hypotheses and ‘‘surprising’’ predictions. I have argued that it is the severity or probativeness of the test—or lack of it—that should determine whether a double-use of data is admissible. I examine a number of surprising ambiguities and unexpected facts that continue to bedevil this debate.

Categories: double-counting, Error Statistics, philosophy of science, Statistics | 36 Comments

The error statistician has a complex, messy, subtle, ingenious, piece-meal approach

RMM: "A Conversation Between Sir David Cox & D.G. Mayo"A comment today by Stephen Senn leads me to post the last few sentences of my (2010) paper with David Cox, “Frequentist Statistics as a Theory of Inductive Inference”:

A fundamental tenet of the conception of inductive learning most at home with the frequentist philosophy is that inductive inference requires building up incisive arguments and inferences by putting together several different piece-meal results; we have set out considerations to guide these pieces[i]. Although the complexity of the issues makes it more difficult to set out neatly, as, for example, one could by imagining that a single algorithm encompasses the whole of inductive inference, the payoff is an account that approaches the kind of arguments that scientists build up in order to obtain reliable knowledge and understanding of a field.” (273)[ii]

A reread for Saturday night?

[i]The pieces hang together by dint of the rationale growing out of a severity criterion (or something akin but using a different term.)

[ii]Error and Inference: Recent Exchanges on Experimental Reasoning, Reliability and the Objectivity and Rationality of Science (D Mayo and A. Spanos eds.), Cambridge: Cambridge University Press: 1-27. This paper appeared in The Second Erich L. Lehmann Symposium: Optimality, 2006, Lecture Notes-Monograph Series, Volume 49, Institute of Mathematical Statistics, pp. 247-275.

Categories: Bayesian/frequentist, Error Statistics | 20 Comments

Blog Contents for Oct and Nov 2013*

2208388671_0d8bc38714

2 tough months in exile

October 2013

  • (10/3) Will the Real Junk Science Please Stand Up? (critical thinking)
  • (10/5) Was Janina Hosiasson pulling Harold Jeffreys’ leg?
  • (10/9) Bad statistics: crime or free speech (II)? Harkonen update: Phil Stat / Law /Stock
  • (10/12) Sir David Cox: a comment on the post, “Was Hosiasson pulling Jeffreys’ leg?”
  • (10/19) Blog Contents: September 2013
  • (10/19) Bayesian Confirmation Philosophy and the Tacking Paradox (iv)*
  • (10/25) Bayesian confirmation theory: example from last post…
  • (10/26) Comedy hour at the Bayesian (epistemology) retreat: highly probable vs highly probed (vs what ?)
  • (10/31) WHIPPING BOYS AND WITCH HUNTERS

November 2013

  • (11/02) Oxford Gaol: Statistical Bogeymen
  • (11/04) Forthcoming paper on the strong likelihood principle
  • (11/09) Null Effects and Replication
  • (11/09) Beware of questionable front page articles warning you to beware of questionable front page articles (iii)
  • (11/13) T. Kepler: “Trouble with ‘Trouble at the Lab’?” (guest post)
  • (11/16) PhilStock: No-pain bull
  • (11/16) S. Stanley Young: More Trouble with ‘Trouble in the Lab’ (Guest post)
  • (11/18) Lucien Le Cam: “The Bayesians hold the Magic”
  • (11/20) Erich Lehmann: Statistician and Poet
  • (11/23) Probability that it is a statistical fluke [i]
  • (11/27) “The probability that it be a statistical fluke” [iia]
  • (11/30) Saturday night comedy from a Bayesian diary (rejected post, see link)

*compiled by N. Jinn & J. Miller

Categories: blog contents, Statistics | Leave a comment

Why ecologists might want to read more philosophy of science

Jeremy Fox often publishes interesting blogposts like today’s. I’m “reblogging” straight from his site as an experiment.

Categories: Error Statistics | 12 Comments

FDA’S New Pharmacovigilance

FDA’s New Generic Drug Labeling Rule

The FDA is proposing an about-face on a controversial issue: to allow (or require? [1]) generic drug companies to alter the label on drugs, whereas they are currently  required to keep the identical label as used by the brand-name company (See earlier post here and here.) While it clearly makes sense to alert the public to newly found side-effects, this change, if adopted, will open generic companies to lawsuits to which they’d been immune (as determined by a 2011 Supreme Court decision).  Whether or not the rule passes, the FDA is ready with a training session for you!  The following is from the notice I received by e-mail: Continue reading

Categories: Announcement, PhilStatLaw, science communication | 4 Comments

Stephen Senn: Dawid’s Selection Paradox (guest post)

Stephen SennStephen Senn
Head, Methodology and Statistics Group,
Competence Center for Methodology and Statistics (CCMS),
Luxembourg

“Dawid’s Selection Paradox”

You can protest, of course, that Dawid’s Selection Paradox is no such thing but then those who believe in the inexorable triumph of logic will deny that anything is a paradox. In a challenging paper published nearly 20 years ago (Dawid 1994), Philip Dawid drew attention to a ‘paradox’ of Bayesian inference. To describe it, I can do no better than to cite the abstract of the paper, which is available from Project Euclid, here: http://projecteuclid.org/DPubS/Repository/1.0/Disseminate?

 When the inference to be made is selected after looking at the data, the classical statistical approach demands — as seems intuitively sensible — that allowance be made for the bias thus introduced. From a Bayesian viewpoint, however, no such adjustment is required, even when the Bayesian inference closely mimics the unadjusted classical one. In this paper we examine more closely this seeming inadequacy of the Bayesian approach. In particular, it is argued that conjugate priors for multivariate problems typically embody an unreasonable determinism property, at variance with the above intuition.

I consider this to be an important paper not only for Bayesians but also for frequentists, yet it has only been cited 14 times as of 15 November 2013 according to Google Scholar. In fact I wrote a paper about it in the American Statistician a few years back (Senn 2008) and have also referred to it in a previous blogpost (12 May 2012). That I think it is important and neglected is excuse enough to write about it again.

Philip Dawid is not responsible for my interpretation of his paradox but the way that I understand it can be explained by considering what it means to have a prior distribution. First, as a reminder, if you are going to be 100% Bayesian, which is to say that all of what you will do by way of inference will be to turn a prior into a posterior distribution using the likelihood and the operation of Bayes theorem, then your prior distribution has to satisfy two conditions. First, it must be what you would use to bet now (that is to say at the moment it is established) and second no amount of subsequent data will change your prior qua prior. It will, of course, be updated by Bayes theorem to form a posterior distribution once further data are obtained but that is another matter. The relevant time here is your observation time not the time when the data were collected, so that data that were available in principle but only came to your attention after you established your prior distribution count as further data.

Now suppose that you are going to make an inference about a population mean, θ, using a random sample from the population and choose the standard conjugate prior distribution. Then in that case you will use a Normal distribution with known (to you) parameters μ and σ2. If σ2 is large compared to the random variation you might expect for the means in your sample, then the prior distribution is fairly uninformative and if it is small then fairly informative but being uninformative is not in itself a virtue. Being not informative enough runs the risk that your prior distribution is not one you might wish to use to bet now and being too informative that your prior distribution is one you might be tempted to change given further information. In either of these two cases your prior distribution will be wrong. Thus the task is to be neither too informative nor not informative enough. Continue reading

Categories: Bayesian/frequentist, selection effects, Statistics, Stephen Senn | 69 Comments

Saturday night comedy from a Bayesian diary (rejected post*)

ccr20011001bb_s04-1*See “rejected posts”.

Categories: Comedy, Rejected Posts, strong likelihood principle | 1 Comment

“The probability that it be a statistical fluke” [iia]

imagesMy rationale for the last post is really just to highlight such passages as:

“Particle physicists have agreed, by convention, not to view an observed phenomenon as a discovery until the probability that it be a statistical fluke be below 1 in a million, a requirement that seems insanely draconian at first glance.” (Strassler)….

Even before the dust had settled regarding the discovery of a Standard Model-like Higgs particle, the nature and rationale of the 5-sigma discovery criterion began to be challenged. But my interest now is not in the fact that the 5-sigma discovery criterion is a convention, nor with the choice of 5. It is the understanding of “the probability that it be a statistical fluke” that interests me, because if we can get this right, I think we can understand a kind of equivocation that leads many to suppose that significance tests are being misinterpreted—even when they aren’t! So given that I’m stuck, unmoving, on this bus outside of London for 2+ hours (because of a car accident)—and the internet works—I’ll try to scratch out my point (expect errors, we’re moving now). Here’s another passage…

“Even when the probability of a particular statistical fluke, of a particular type, in a particular experiment seems to be very small indeed, we must remain cautious. …Is it really unlikely that someone, somewhere, will hit the jackpot, and see in their data an amazing statistical fluke that seems so impossible that it convincingly appears to be a new phenomenon?”

A very sketchy nutshell of the Higgs statistics: There is a general model of the detector, and within that model researchers define a “global signal strength” parameter “such that H0: μ = 0 corresponds to the background only hypothesis and μ = 1 corresponds to the Standard Model (SM) Higgs boson signal in addition to the background” (quote from an ATLAS report). The statistical test may be framed as a one-sided test; the test statistic records differences in the positive direction, in standard deviation or sigma units. The interest is not in the point against point hypotheses, but in finding discrepancies from H0 in the direction of the alternative, and then estimating their values.  The improbability of the 5-sigma excess alludes to the sampling Continue reading

Categories: Error Statistics, P-values, statistical tests, Statistics | 66 Comments

Probability that it is a statistical fluke [i]

cropped-qqqq.jpgFrom another blog:
“…If there are 23 people in a room, the chance that two of them have the same birthday is 50 percent, while the chance that two of them were born on a particular day, say, January 1st, is quite low, a small fraction of a percent. The more you specify the coincidence, the rarer it is; the broader the range of coincidences at which you are ready to express surprise, the more likely it is that one will turn up.

Humans are notoriously incompetent at estimating these types of probabilities… which is why scientists (including particle physicists), when they see something unusual in their data, always try to quantify the probability that it is a statistical fluke — a pure chance event. You would not want to be wrong, and celebrate your future Nobel prize only to receive instead a booby prize. (And nature gives out lots and lots of booby prizes.) So scientists, grabbing their statistics textbooks and appealing to the latest advances in statistical techniques, compute these probabilities as best they can. Armed with these numbers, they then try to infer whether it is likely that they have actually discovered something new or not.

And on the whole, it doesn’t work. Unless the answer is so obvious that no statistical argument is needed, the numbers typically do not settle the question.

Despite this remark, you mustn’t think I am arguing against doing statistics. One has to do something better than guessing. But there is a reason for the old saw: “There are three types of falsehoods: lies, damned lies, and statistics.” It’s not that statistics themselves lie, but that to some extent, unless the case is virtually airtight, you can almost always choose to ask a question in such a way as to get any answer you want. … [For instance, in 1991 the volcano Pinatubo in the Philippines had its titanic eruption while a hurricane (or `typhoon’ as it is called in that region) happened to be underway. Oh, and the collapse of Lehman Brothers on Sept 15, 2008 was followed within three days by the breakdown of the Large Hadron Collider (LHC) during its first week of running… Coincidence?  I-think-so.] One can draw completely different conclusions, both of them statistically sensible, by looking at the same data from two different points of view, and asking for the statistical answer to two different questions.

To a certain extent, this is just why Republicans and Democrats almost never agree, even if they are discussing the same basic data. The point of a spin-doctor is to figure out which question to ask in order to get the political answer that you wanted in advance. Obviously this kind of manipulation is unacceptable in science. Unfortunately it is also unavoidable. Continue reading

Categories: Error Statistics, Severity vs Posterior Probabilities, spurious p values | 22 Comments

Erich Lehmann: Statistician and Poet

Erich Lehmann 20 November 1917 – 12 September 2009

Erich Lehmann                       20 November 1917 –              12 September 2009

Today is Erich Lehmann’s birthday. The last time I saw him was at the Second Lehmann conference in 2004, at which I organized a session on philosophical foundations of statistics (including David Freedman and D.R. Cox).

I got to know Lehmann, Neyman’s first student, in 1997.  One day, I received a bulging, six-page, handwritten letter from him in tiny, extremely neat scrawl (and many more after that).  He told me he was sitting in a very large room at an ASA meeting where they were shutting down the conference book display (or maybe they were setting it up), and on a very long, dark table sat just one book, all alone, shiny red.  He said he wondered if it might be of interest to him!  So he walked up to it….  It turned out to be my Error and the Growth of Experimental Knowledge (1996, Chicago), which he reviewed soon after. Some related posts on Lehmann’s letter are here and here.

That same year I remember having a last-minute phone call with Erich to ask how best to respond to a “funny Bayesian example” raised by Colin Howson. It is essentially the case of Mary’s positive result for a disease, where Mary is selected randomly from a population where the disease is very rare. See for example here. (It’s just like the case of our high school student Isaac). His recommendations were extremely illuminating, and with them he sent me a poem he’d written (which you can read in my published response here*). Aside from being a leading statistician, Erich had a (serious) literary bent.

Juliet Shafer, Erich Lehmann, D. Mayo

Juliet Shafer, Erich Lehmann, D. Mayo

The picture on the right was taken in 2003 (by A. Spanos).

Mayo, D. G (1997a), “Response to Howson and Laudan,” Philosophy of Science 64: 323-333.

(Selected) Books

  • Testing Statistical Hypotheses, 1959
  • Basic Concepts of Probability and Statistics, 1964, co-author J. L. Hodges
  • Elements of Finite Probability, 1965, co-author J. L. Hodges
  • Lehmann, Erich L.; With the special assistance of H. J. M. D’Abrera (2006). Nonparametrics: Statistical methods based on ranks (Reprinting of 1988 revision of 1975 Holden-Day ed.). New York: Springer. pp. xvi+463. ISBN 978-0-387-35212-1. MR 2279708.
  • Theory of Point Estimation, 1983
  • Elements of Large-Sample Theory (1988). New York: Springer Verlag.
  • Reminiscences of a Statistician, 2007, ISBN 978-0-387-71596-4
  • Fisher, Neyman, and the Creation of Classical Statistics, 2011, ISBN 978-1-4419-9499-8 [published posthumously]

Articles (3 of very many)

Categories: philosophy of science, Statistics | Tags: , | Leave a comment

Lucien Le Cam: “The Bayesians hold the Magic”

Nov.18, 1924 -April 25, 2000

Nov.18, 1924 -April 25, 2000

Today is Lucien Le Cam’s birthday. He was an error statistician whose remarks in an article, “A Note on Metastatisics,” in a collection on foundations of statistics (Le Cam 1977)* had some influence on me.  A statistician at Berkeley, Le Cam was a co-editor with Neyman of the Berkeley Symposia volumes. I hadn’t mentioned him on this blog before, so here are some snippets from EGEK (Mayo, 1996, 337-8; 350-1) that begin with a snippet from a passage from Le Cam (1977) (Here I have fleshed it out):

“One of the claims [of the Bayesian approach] is that the experiment matters little, what matters is the likelihood function after experimentation. Whether this is true, false, unacceptable or inspiring, it tends to undo what classical statisticians have been preaching for many years: think about your experiment, design it as best you can to answer specific questions, take all sorts of precautions against selection bias and your subconscious prejudices. It is only at the design stage that the statistician can help you.

Another claim is the very curious one that if one follows the neo-Bayesian theory strictly one would not randomize experiments….However, in this particular case the injunction against randomization is a typical product of a theory which ignores differences between experiments and experiences and refuses to admit that there is a difference between events which are made equiprobable by appropriate mechanisms and events which are equiprobable by virtue of ignorance. …

In spite of this the neo-Bayesian theory places randomization on some kind of limbo, and thus attempts to distract from the classical preaching that double blind randomized experiments are the only ones really convincing.

There are many other curious statements concerning confidence intervals, levels of significance, power, and so forth. These statements are only confusing to an otherwise abused public”. (Le Cam 1977, 158)

Back to EGEK:

Why does embracing the Bayesian position tend to undo what classical statisticians have been preaching? Because Bayesian and classical statisticians view the task of statistical inference very differently,

In [chapter 3, Mayo 1996] I contrasted these two conceptions of statistical inference by distinguishing evidential-relationship or E-R approaches from testing approaches, … .

The E-R view is modeled on deductive logic, only with probabilities. In the E-R view, the task of a theory of statistics is to say, for given evidence and hypotheses, how well the evidence confirms or supports hypotheses (whether absolutely or comparatively). There is, I suppose, a certain confidence and cleanness to this conception that is absent from the error-statistician’s view of things. Error statisticians eschew grand and unified schemes for relating their beliefs, preferring a hodgepodge of methods that are truly ampliative. Error statisticians appeal to statistical tools as protection from the many ways they know they can be misled by data as well as by their own beliefs and desires. The value of statistical tools for them is to develop strategies that capitalize on their knowledge of mistakes: strategies for collecting data, for efficiently checking an assortment of errors, and for communicating results in a form that promotes their extension by others.

Given the difference in aims, it is not surprising that information relevant to the Bayesian task is very different from that relevant to the task of the error statistician. In this section I want to sharpen and make more rigorous what I have already said about this distinction.

…. the secret to solving a number of problems about evidence, I hold, lies in utilizing—formally or informally—the error probabilities of the procedures generating the evidence. It was the appeal to severity (an error probability), for example, that allowed distinguishing among the well-testedness of hypotheses that fit the data equally well… .

A few pages later in a section titled “Bayesian Freedom, Bayesian Magic” (350-1):

 A big selling point for adopting the LP (strong likelihood principle), and with it the irrelevance of stopping rules, is that it frees us to do things that are sinful and forbidden to an error statistician.

“This irrelevance of stopping rules to statistical inference restores a simplicity and freedom to experimental design that had been lost by classical emphasis on significance levels (in the sense of Neyman and Pearson). . . . Many experimenters would like to feel free to collect data until they have either conclusively proved their point, conclusively disproved it, or run out of time, money or patience … Classi­cal statisticians … have frowned on [this]”. (Edwards, Lindman, and Savage 1963, 239)1

Breaking loose from the grip imposed by error probabilistic requirements returns to us an appealing freedom.

Le Cam, … hits the nail on the head:

“It is characteristic of [Bayesian approaches] [2] . . . that they … tend to treat experiments and fortuitous observations alike. In fact, the main reason for their periodic return to fashion seems to be that they claim to hold the magic which permits [us] to draw conclusions from what­ever data and whatever features one happens to notice”. (Le Cam 1977, 145)

In contrast, the error probability assurances go out the window if you are allowed to change the experiment as you go along. Repeated tests of significance (or sequential trials) are permitted, are even desirable for the error statistician; but a penalty must be paid for perseverance—for optional stopping. Before-trial planning stipulates how to select a small enough significance level to be on the lookout for at each trial so that the overall significance level is still low. …. Wearing our error probability glasses—glasses that compel us to see how certain procedures alter error probability characteristics of tests—we are forced to say, with Armitage, that “Thou shalt be misled if thou dost not know that” the data resulted from the try and try again stopping rule. To avoid having a high probability of following false leads, the error statistician must scrupulously follow a specified experimental plan. But that is because we hold that error probabilities of the procedure alter what the data are saying—whereas Bayesians do not. The Bayesian is permitted the luxury of optional stopping and has nothing to worry about. The Bayesians hold the magic.

Or is it voodoo statistics?

When I sent him a note, saying his work had inspired me, he modestly responded that he doubted he could have had all that much of an impact.
_____________

*I had forgotten that this Synthese (1977) volume on foundations of probability and statistics is the one dedicated to the memory of Allan Birnbaum after his suicide: “By publishing this special issue we wish to pay homage to professor Birnbaum’s penetrating and stimulating work on the foundations of statistics” (Editorial Introduction). In fact, I somehow had misremembered it as being in a Harper and Hooker volume from 1976. The Synthese volume contains papers by Giere, Birnbaum, Lindley, Pratt, Smith, Kyburg, Neyman, Le Cam, and Kiefer.

REFERENCES:

Armitage, P. (1961). Contribution to discussion in Consistency in statistical inference and decision, by C. A. B. Smith. Journal of the Royal Statistical Society (B) 23:1-37.

_______(1962). Contribution to discussion in The foundations of statistical inference, edited by L. Savage. London: Methuen.

_______(1975). Sequential Medical Trials. 2nd ed. New York: John Wiley & Sons.

Edwards, W., H. Lindman & L. Savage (1963) Bayesian statistical inference for psychological research. Psychological Review 70: 193-242.

Le Cam, L. (1974). J. Neyman: on the occasion of his 80th birthday. Annals of Statistics, Vol. 2, No. 3 , pp. vii-xiii, (with E.L. Lehmann).

Le Cam, L. (1977). A note on metastatistics or “An essay toward stating a problem in the doctrine of chances.”  Synthese 36: 133-60.

Le Cam, L. (1982). A remark on empirical measures in Festschrift in the honor of E. Lehmann. P. Bickel, K. Doksum & J. L. Hodges, Jr. eds., Wadsworth  pp. 305-327.

Le Cam, L. (1986). The central limit theorem around 1935. Statistical Science, Vol. 1, No. 1,  pp. 78-96.

Le Cam, L. (1988) Discussion of “The Likelihood Principle,” by J. O. Berger and R. L. Wolpert. IMS Lecture Notes Monogr. Ser. 6 182–185. IMS, Hayward, CA

Le Cam, L. (1996) Comparison of experiments: A short review. In Statistics, Probability and Game Theory. Papers in Honor of David Blackwell 127–138. IMS, Hayward, CA.

Le Cam, L.,  J. Neyman and E. L. Scott (Eds). (1973). Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability, Vol. l: Theory of Statistics, Vol. 2: Probability Theory, Vol. 3: Probability Theory. Univ. of Calif. Press, Berkeley Los Angeles.

Mayo, D. (1996). [EGEK] Error Statistics and the Growth of Experimental Knowledge. Chicago: University of Chicago Press. (Chapter 10; Chapter 3)

Neyman, J. and L. Le Cam (Eds). (1967).  Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, Vol. I: Statistics, Vol. II: Probability Part I & Part II. Univ. of Calif. Press, Berkeley and Los Angeles.

[1] For some links on optional stopping on this blog: Highly probably vs highly probed: Bayesian/error statistical differences.Who is allowed to cheat? I.J. Good and that after dinner comedy hour….New SummaryMayo: (section 7) “StatSci and PhilSci: part 2″After dinner Bayesian comedy hour….; Search for more, if interested.

[2] Le Cam is alluding mostly to Savage, and (what he called) the “neo-Bayesian” accounts.

Categories: Error Statistics, frequentist/Bayesian, phil/history of stat, strong likelihood principle | 58 Comments

S. Stanley Young: More Trouble with ‘Trouble in the Lab’ (Guest post)

 Stanley Young’s guest post arose in connection with Kepler’s Nov. 13, and my November 9 post,and associated comments.

YoungPhoto2008S. Stanley Young, PhD Assistant Director for Bioinformatics National Institute of Statistical Sciences Research Triangle Park, NC

Much is made by some of the experimental biologists that their art is oh so sophisticated that mere mortals do not have a chance [to successfully replicate]. Bunk. Agriculture replicates all the time. That is why food is so cheap. The world is growing much more on fewer acres now than it did 10 years ago. Materials science is doing remarkable things using mixtures of materials. Take a look at just about any sports equipment. These two areas and many more use statistical methods: design of experiments, randomization, blind reading of results, etc. and these methods replicate, quite well, thank you. Read about Edwards Deming. Experimental biology experiments are typically run by small teams in what is in effect a cottage industry. Herr professor is usually not in the lab. He/she is busy writing grants. A “hands” guy is in the lab. A computer guy does the numbers. No one is checking other workers’ work. It is a cottage industry to produce papers.

There is a famous failure to replicate that appeared in Science.  A pair of non-estrogens was reported to have a strong estrogenic effect. Six labs wrote into Science saying the could not replicate the effect. I think the back story is as follows. The hands guy tested a very large number of pairs of chemicals. The most extreme pair looked unusual. Lab boss said, write it up. Every assay has some variability, so they reported extreme variability as real. Failure to replicate in six labs. Science editors says, what gives. Lab boss goes to hands guy and says run the pair again. No effect. Lab boss accuses hands guy of data fabrication. They did not replicate their own finding before rushing to publish. I asked the lab for the full data set, but they refused to provide the data.  The EPA is still chasing this will of the wisp, environmental estrogens. False positive results with compelling stories can live a very long time. See [i].

Begley and Ellis visited labs. They saw how the work was done. There are instances where something was tried over and over and when it worked “as expected”, it was a rap. Write the paper and move on. I listened to a young researcher say that she tried for 6 months to replicate results of a paper. Informal conversations with scientists support very poor replication.

One can say that the jury is out as there have been few serious attempts to systematically replicate. There is now starting systematic replication. I say less than 50% of experimental biology claims will replicate.

[i]Hormone Hysterics. Tulane University researchers published a 1996 study claiming that combinations of manmade chemicals (pesticides and PCBs) disrupted normal hormonal processes, causing everything from cancer to infertility to attention deficit disorder.

Media, regulators and environmentalists hailed the study as “astonishing.” Indeed it was as it turned out to be fraud, according to an October 2001 report by federal investigators. Though the study was retracted from publication, the law it spawned wasn’t and continues to be enforced by the EPA. Read more…

Categories: evidence-based policy, junk science, Statistical fraudbusting, Statistics | 20 Comments

PhilStock: No-pain bull

stock picture smaillSee rejected posts.  

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T. Kepler: “Trouble with ‘Trouble at the Lab’?” (guest post)

Tom Kepler’s guest post arose in connection with my November 9 post & comments.

Kepler--Thomas-1x1.4

Professor Thomas B. Kepler
Department of Microbiology
Department of Mathematics & Statistics
Boston University School of Medicine

There is much to say about the article in the Economist, but the first is to note that it is far more balanced than its sensational headline promises. Promising to throw open the curtain on “Unreliable research” is mere click-bait for the science-averse readers who have recently found validation against their intellectual insecurities in the populist uprising against the shadowy world of the scientist. What with the East Anglia conspiracy, and so on, there’s no such thing as “too skeptical” when it comes to science.

There is some remarkably casual reporting in an article that purports to be concerned with mechanisms to assure that inaccuracies not be perpetuated.

For example, the authors cite the comment in Nature by Begley and Ellis and summarize it thus: …scientists at Amgen, an American drug company, tried to replicate 53 studies that they considered landmarks in the basic science of cancer, often co-operating closely with the original researchers to ensure that their experimental technique matched the one used first time round. Stan Young, in his comments to Mayo’s blog adds, “These claims can not be replicated – even by the original investigators! Stop and think of that.” But in fact the role of the original investigators is described as follows in Begley and Ellis: “…when findings could not be reproduced, an attempt was made to contact the original authors, discuss the discrepant findings, exchange reagents and repeat experiments under the authors’ direction, occasionally even in the laboratory of the original investigator.” (Emphasis added.) Now, please stop and think about what agenda is served by eliding the tempered language of the original.

Both the Begley and Ellis comment and the brief correspondence by Prinz et al. also cited in this discussion are about laboratories in commercial pharmaceutical companies failing to reproduce experimental results. While deciding how to interpret their findings, it would be prudent to bear in mind the insight from Harry Collins, the sociologist of science paraphrased in the Economist piece as indicating that “performing an experiment always entails what sociologists call “tacit knowledge”—craft skills and extemporisations that their possessors take for granted but can pass on only through example. Thus if a replication fails, it could be because the repeaters didn’t quite get these je-ne-sais-quoi bits of the protocol right.” Indeed, I would go further and conjecture that few experimental biologists would hold out hope that any one laboratory could claim the expertise necessary to reproduce the results of 53 ground-breaking papers in diverse specialties, even within cancer drug discovery. And to those who are unhappy that authors often do not comply with the journals’ clear policy of data-sharing, how do you suppose you would fare getting such data from the pharmaceutical companies that wrote these damning papers? Or the authors of the papers themselves? Nature had to clarify, writing two months after the publication of Begley and Ellis, “Nature, like most journals, requires authors of research papers to make their data available on request. In this less formal Comment, we chose not to enforce this requirement so that Begley and Ellis could abide by the legal agreements [they made with the original authors].” Continue reading

Categories: junk science, reforming the reformers, science communication, Statistics | 20 Comments

Beware of questionable front page articles warning you to beware of questionable front page articles (iii)

RRIn this time of government cut-backs and sequester, scientists are under increased pressure to dream up ever new strategies to publish attention-getting articles with eye-catching, but inadequately scrutinized, conjectures. Science writers are under similar pressures, and to this end they have found a way to deliver up at least one fire-breathing, front page article a month. How? By writing minor variations on an article about how in this time of government cut-backs and sequester, scientists are under increased pressure to dream up ever new strategies to publish attention-getting articles with eye-catching, but inadequately scrutinized, conjectures.

Thus every month or so we see retreads on why most scientific claims are unreliable,  biased, wrong, and not even wrong. Maybe that’s the reason the authors of a recent article in The Economist (“Trouble at the Lab“) remain anonymous.

I don’t disagree with everything in the article; on the contrary, part of their strategy is to include such well known problems as publication bias, problems with priming studies in psychology, and failed statistical assumptions. But the “big news”–the one that sells– is that “to an alarming degree” science (as a whole) is not reliable and not self-correcting. The main evidence is that there are the factory-like (thumbs up/thumbs down) applications of statistics in exploratory, hypotheses generating contexts wherein the goal is merely screening through reams of associations to identify a smaller batch for further analysis. But do even those screening efforts claim to have evidence of a genuine relationship when a given H is spewed out of their industrial complexes? Do they go straight to press after one statistically significant result?  I don’t know, maybe some do. What I do know is that the generalizations we are seeing in these “gotcha” articles are every bit as guilty of sensationalizing without substance as the bad statistics they purport to be impugning. As they see it, scientists, upon finding a single statistically significant result at the 5% level, declare an effect real or a hypothesis true, and then move on to the next hypothesis. No real follow-up scrutiny, no building on discrepancies found, no triangulation, self-scrutiny, etc.

But even so, the argument which purports to follow from “statistical logic”, but which actually is a jumble of “up-down” significance testing, Bayesian calculations, and computations that might at best hold for crude screening exercises (e.g., for associations between genes and disease) commits blunders about statistical power, and founders. Never mind that if the highest rate of true outputs was wanted, scientists would dabble in trivialities….Never mind that I guarantee if you asked Nobel prize winning scientists the rate of correct attempts vs blind alleys they went through before their Prize winning results, they’d say far more than 50% errors,  (Perrin and Brownian motion, Prusiner and Prions, experimental general relativity, just to name some I know.)

But what about the statistics? Continue reading

Categories: junk science, P-values, Statistics | 52 Comments

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